                          ˿µϣ20090213գ

09.02.13, ӡţOMPţ̵Ļԡ
09.02.13, Yushţʣţ˶Ǯ
09.02.13, ţˡ
09.02.13, ںӡţжǵıݡ
09.02.13, S࣬Ҫô°Ҫôթƭ
09.02.13, ϺαרҳţӦٻOMP
09.02.13, ʱţOMPΣ
09.02.13, ù۲챨ţOMPս
09.02.13, »רΪOMPţ̲Σ
09.02.13, OMPMBP˵
09.02.13, ֳʱ¼ ѧ߳ţ˵
09.02.13, ձݲֳнƾСƱ˻
09.02.13, Ӫѧר
09.02.13, 6вֳ¼ţţ
09.02.13, κӢܡյĸ߼۾OMP
09.02.13, Сࡶ˭ڡݺţ
09.02.13, ⺼OMP֪Ȩ١
09.02.13, ӡʼ칤ʱ̡ܴ
09.02.13, toxysʵΪ۳дѧïʵġ
09.02.13, 98и˼ġҩִǲܡ
09.02.13, ｭҩ޹˾ľ˹ֹ˾˫עҺͣ

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                       ţOMPţ̵Ļ

                              ӡ

ţOMPţ̵ĻӦгƣOMPǹоʹöţ
ԵMBP䰲ȫܵFDAȹȨϿɡMBP˰
FDA(Food and Drug AdministrationʳƷҽҩƷ)GRAS(Generally 
Recognized As Safe)֤ũҵҵʳƷȫ֤ȶȨ֤
FDAġȫʱ(2007629)֤ΪGRN No196FDA涨
MBPʹʳƷУҶκơ

ǰѾָţOMPţ̵ϡרоԱ
׫дģνOMPIGF-1IGF-1ΪҪɷ֣ʲôMBPһ
˵OMPMBPMBPľţ˵䰲ȫܵFDAȹ
ȨϿɡFDA涨MBPʹʳƷУҶκ
ơ𣿻شǷ񶨵ġţһԡţMBPFDA
ȫʱе֤ΪGRN No196ʵϣGRN 00019ʲô֤ţ
ϱţձѩӡţ̹˾˾йʳƷӡţ̼Ե
֡BMBPFİȫϱFDAıšFDAڴʱָ

ѩӡ˾ṩĲϣԼFDAõϢĿǰѩ
ӡ˾BMBPFʹõڡһΪȫĽۡǣ
ڴʹBMBPFǷڡһΪȫֲԼľ
ͨһѩӡ˾Ӧȷù˾۵ʳɷǰȫģ
õķɷ档Based on the information provided by 
Snow Brand, as well as other information available to FDA, the agency 
has no questions at this time regarding Snow Brand's conclusion that 
BMBPF is GRAS under the intended conditions of use. The agency has not, 
however, made its own determination regarding the GRAS status of the 
subject use of BMBPF. As always, it is the continuing responsibility 
of Snow Brand to ensure that food ingredients that the firm markets 
are safe, and are otherwise in compliance with all applicable legal 
and regulatory requirements. 
http://www.cfsan.fda.gov/~rdb/opa-g196.html

ɼFDA϶BMBPFǷȫֻĿǰѩӡ˾Ϊ䰲ȫ
ۣڸôУFDAҲû˵MBPʹʳƷУҶ
κơʹѩӡ˾Ҳô˵Ǹݶʵ
ȫ˹ƣƻMBPΪʳƷɷӵΪÿʳ1040ˡ

ţOMPţ̵ĻӦֳƣţOMPԭϾTATUA
˾ڣԭϾ˺غͽڼ߲ϸ顣TATUA˾
ļ֤OMPţ̼ԵMBPTATUA˾ţȡȫ
ЩҲ20ʷרΪЩţ̵ʵİ
ȫбϵġ

ǲTATUA˾վϵĲƷĿ¼С嵰Ũ
MBPhttp://www.tatua.com/dairy/Ingredientsѵù˾صΪţ
MBPţ嵰ȫMBPƷҲ嵰ף
ҲOMPƷҽѧ׿֪ţ嵰׵ļ
һ˵ձѩӡţ̹˾оԱ1996ģTakada Y, Aoe S, 
Kumegawa M, Biochem Biophys Res Commun. 1996 Jun 14;223(2):445-9.
Ҳֻ12꣬ôTATUA˾ܡţȡȫЩ
Ҳ20ʷ

(XYS20090213)

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ţʣţ˶Ǯ

ߣYush

ÿ250mlţOMPţOMP20mgϣÿ100ںOMP8.0
ˡһ12м۸60ԪţʳƷȫ֤2007
ţTatua˾θ 721.05059.750kgġţ̵(OMP)ʵΪ
סLactoferrin co-isolateӵһںOMP
ţУ۶5Ԫ۸ͨţ̸һңţԼ2.5
Ԫ

ţ̵(OMP)Ǯһɲοƣӣ
׵ۼۡ

ǰTatuaй׼谷ıÿԼ34
Ԫÿ340ԪԼ2400ԪңÿOMPţеġ
ţ̵(OMP)ɱΪ5Ǯţ2.5OMPɱ190
Ԫ

(XYS20090213)

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ţ

ߣ

ӶţOMPɣѾúˡʼܾ
ͣţOMP̣ǲ뷽ɶеϵڵҲ
ù²⡣OMPˣҲס뵽ţŵվȥ
ţǰìܵOMPܷһɵ㲻˵
ţˡ

йӮȫҵ֮------ţҵйӮ
ҵߴ󽱡IDF²Ʒ (2006-10-27)

http://www.mengniu.com.cn/newsfile/2006102715180499056.asp?ID=177  

ƪǰƣţҹӪ뷢չģѧҽ
ѧԺͬзġţ̵(ӢдOMP)Ӧõţ֮У
Ƴϵһܡơܡסơţ̡

ţOMP̵ĻӦ (2009212)) 
http://www.mengniu.com.cn/newsfile/20092129445735717.asp?ID=527

Ӧĵ1дOMPţΪԭϣ֬Ĥ˵ȹƳɵ
ţ̼ԵʻҪɷΪףøȣţ
ƷзTATUA˾ͬоġ

Ӧĵ2ǣOMPǹоʹöţ̼ԵMBP

ףȻʶMBPǰţΪɶԴһOMPˣȻǹͨ
õġţ̼ԵʡǰţΪɶԴһţ̵סˣ
ȻǴTATUAƷ˾ģǰô롰ҹӪ뷢չ
ģѧҽѧԺͬзġϵһˣ

(XYS20090213)

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ţжǵı

ߣں

ʼܾڳʰˡҵŬµջ˵ʳ
ƷȫȻϾÿһСҲֵοġ

ţжǱֵúܷ񡣱ҲĲ˼ˡֻ
ǣЩ˵Ϊ棬óһ£* Ϊеĸ߼#Ϊ
ļ

*Һնû
#ھŴүһ̣80꣬ǲ̶Խ޺
˵ձ̹ͨöֻ࣬޺Ҳ

*ҲҲû£ǲҪʷһǰ
#񰡡ţǮ

*λϴʵȷ£ϴһ
ҵʲôĺʲôĺΪһȨ
ȨӦʵ˵/
#ţϡͿƭǮȴ˵ʲô߼

*¥˵.Ҫ˵,Ϊʲôһ
*Բ˵Ҫ°ĻͲˣȫҥԡҺ
2ҲûºǺǡ
#ϧ⻰˵˵㡣ձͣˣʲô˵ģ̧׳
ڱͣôԹԵطʡؽƱ磿

*˵˵Ǹġ˵Ѽ⣬˵⣬
˵ܲԡɶԼģţƲԷգʲôϲǵ
ڻʣʲôƷڿƼװˣ⣬
Ļˣ
#Ķ࣬ӦСģ֪ĸҪ⡣ѵ
֪⻹ǵȥԣ˵û߼Ļպȶ˰:)

*Ǹʲôרѽ,ǰȥ,նкü,
˵.ݺţ.˼ҸǮ.СĹ.ţ˲ȱ.
#ļһ֣вġǰһվˡ
˼ҸǮôûƷζжţ˲ȱ¡
̡ܷ

*Щ˾Ǽţķٷչ
*¥ڶʼյĳɹ.Զ֧ţ
# ֺûʲô˵ģһͣ
ΪʡΪʲôʼ΢ΪʲôʼgoogleΪʲô
ɿɿڿ֣ΪʲôʼɺΪʲôƫƫҪʼ캦ı
޳ܡΪţЦ

(XYS20090213)

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࣬Ҫô°Ҫôթƭ

ߣS

    ţˣţաţӵһOMPʣһ
ʹϵ°ʡ

¹¼ţţʵд˷⹫ţʾԼ
谷ҵǱ֪飬ҪơΪԲеİ
ֹ̫࣬Ҳţ¹Ѿ̨ţȴúܺá

ţһޱȵţƷ֣Сաţ̣ųǽţ̣
鶼ơգϺġÿվš¶ʼܾ
ţ˾ֹաţOMPʣ˴ǹٷ״ζţġOMP
б̬ǰý巢ţţ̺OMP°ɣȫ
ţ˾ø߶ĹѺ͹طѰƽ

ʵ2007꣬Ҿ͸߲ϸߵѣţĸ߶ţ
աеOMPʣһ°ʣûšع
ֵܾı̬һЩˡ

ա°ٶʿ˿վ¶
֮ţ˾Ľͣʵܼ򵥡ӷ֣
ţ˾ԼνOMPʣеָIGF-1ȫǺϡ
IGF-1ʣѧȵӣֻҪﻯѧݿһ飬
֪һּ൰ףǹʹϵ°ʡĵϻ
껭һģһϲôɺϵ飬ͬҲ
ֵʣָȫǺϣһģһġ

ΪʲôţĽͣΪǵĽͼû֤ݣû߼ţ
˵OMPʣOsteoblasts Milk ProteinţԼģ
IGF-1ͬһʡʲôأ־͹OMPʵĽṹʽ
ôŲͬһʣ

ţڳϣԼOMPǴڵģǾ
ص֤2005꣬ţƻһֱƣҹҵƼȡ
ͻƣȫ׿OMP鵰ţOMPԼģ
ӵжרţȴ˵ŷޡձȹѾ
ʹö꣬ǽMBPMilk Basic ProteinǰǶ
شͻƾ˵ѡƭΥйطɣȫթƭ

ȻձMBPţΪɶҪOMPأʵ˵˺ܼ򵥣һ
ԴԼǱһ֣Ϳڹϵﻯѧ
ݿţͿ㴵ʵĹЧˡţ־͹
OMPʵĽṹʽϾͿ֪ձMBPǷͬһʡ

ʵˣʲôǽţ̣ʲô鶼ȫƵĸ
νӪֶζѡڣһЩȡĸ߿Ƽα
ƼƳһʱУĿɵðĿɵ椶ǣһȻѧ
ʶҲûС׹ġ԰׽𡱣ʵ԰׽־
ƵģҪɷ־ʺڼأ˵ʲô԰׽𡱡ʺڼǴɹ
ڵһִٽ˯ߵļأÿ°δ˷ã
ΣЩĳʶѡȥ԰׽𡱵ϣֱ
˰ΰٲҩˡ

ţҪô°ҪôթƭͿѡһˡ
ţաţ°¼ᵼţ¹³
Ų֮󣬱йţĸ汨ȫʧϰջ
ɵļţ°ţ̡

˵һ£һЩνĽ飬˵ʲôţ̱ţ
ģ˺Ȳ˺ţҪ°ȵȣЩȫǺ˵˵ܶýѾ
飬νߣƭӣǽҽȻô
ţ˵˵Ŀѧʵ̫ţ̱ǲ°ģ˵
ֻǡţӵʣһֹʹϵ°ʡ

(XYS20090213)

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רҳţӦٻOMP

2009-02-13Ϻα

α ӱ ϰ Ө ķʵϰ  

 ţOMP°ʣԺˣһ磬ѧ
ο±ȺѣǲҪٺյOMPţ̡ 
ҿý屨OMPкȻʼֱܾʾԸʵİȫ
ԻоУϣע㡣

OMPܲܺҲۣһȴ۽˴ҵĿ⣬ 22
֮ǰô죿죬ְܲžʾĿǰûٻػͣ۵
˵ɣʼֹֽܾţ˾OMPԹڰȫΪ֮
٣ ԶԶѧߺרҶΪţӦٻOMPգ
ԱߵĺϷȨ档

ѧרųԱѧʳƷȫרЧָ
 ӼĿ¼ûгֵʣκ̼ӵĳɷֶǲ
ģӣӦΥ谷OMPƷƵƵ
Ӽ⣬ìͷ׼̼ƺҲʧʡЧָҹûа
 ʳƷȫţ OMPա¼Ӻ̶ܴ͹ҹʳƷ
ϵ©



OMPţڸ

¼Եǣලֽܾշһ⺯ٴ
ƷҵĲ ҹδOMPİȫ涨 IGF-1Ҳ
ͳʳƷԭϣҪɹලţ˾ֹţ
OMPIGF-1ʡ

ˣţǰʽӦƣҵ22ͣOMP,
OMP봫ָ°IGF-1ȫһʡ

һʯǧˣṫڶʳǷȫʾǿҵĹע

磬ֶĳŵ꿴 112
OMPţۣΪ59.9Ԫ/䡣ߴţ̵İװϿţе 
OMPڵ8ˡ ơΪţǲǻΪ
ÿ8ϵOMPӶ𵽲Чأ޶ ʳƷȫ 
з֣ ʳƷʳƷӼıǩ˵顢װú١
ݣ漰ԤơϹܡȱȻһּ
ݿѧ֤ȱƻ109ּķ

У߻ţţ̹4Ʒ֣
̡ݸóеĺξܣл̵Ϊ6䣬OMPΪ15䡣
ȣOMPѾ½˽40%

ýOMP°Ϣξʾ֪飬ƣ
һֱúܺãܶ˿һŵҪľ˵ 
ǵţ ɻ ʪ֮֡ ɻǳ۵ţ
̣ ʪǷع۵ţ̡ ɻ
վõġ

ڼָ꣬߷֣ OMP̹רȻռҪλ
áһԵţԱڷذװա OMP°
˵ʾû˵ղˣǲƵģڵѡ
ţƷŮʿ߼ߣ ˵OMP°ϢҲ
ˡ

漴߷һЩС͵ıꡣСľ·Եۿ۵꣬Ա 
ǻûнӵţ¼֪ܵͨСľ·ţר
Աʾ11սӵ˾Ҫ¼յ֪ͨ

Ӧ

ݲOMPţٻػͣ

гϵķѿְܲŶOMPûвȡٻػͣ
۵Ĵʩκһƿ°ʳûȷǾ԰ȫʱҲ
ͬ޷߷ĵʳáɴˣOMPţǷӦٻء˹
ڹĵ⡣

죬ʼಿȡϵòйʿʾѾ֪
£ţ̵ĲزϺϺгϵͨ
ϽΧڣҲûлµϢ

й̲йʿʾĿǰӵOMPǷȫڽ
һĵ飬ڽ֮ǰ̲Ų֪̼ͨҳʳƷҩƷල
йʿƣOMPʵİȫûйٷ֮ǰǲִ顣

زŽ̬ȲͬǣרҵĿȻ ܶࡣ

ѧרųԱѧʳƷȫרЧָţ
ĿǰԴOMPյгƲȡǷǳ̬ȣ ȷӦǣ
ţٻOMPգԱߵĺϷȨ档

ЧΪʳƷͬĹҵƷƷ ʳƷһ
գɲصľ档ͬʱܶʳƷɵǱڽϳ
ԺڵΣԤơ

Ч˵ ʹһOMPձΪ޺ʣĿǰţ
ҲӦٻOMPƷΪOMPûбڹӼָĿ¼ϡ 
Դˣ߾һӣ ȥָעˮ¼Ȼ
עˮⲢ𺦣ǷԸʳעˮ⣬ע
Ǵˮ

ɣʼֹֽܾţ˾OMPԹڰȫΪ
 ԶԶѧ߷ڽܱ߲ɷʱʾĿǰ
ţ̵ϴ󣬶ţ̴Űȫţ
ǷĶкڰȫԲȷʱͣ۵ĴӦ
Ϊ׵ġ

۵

OMPաǷթ

OMPûбڹӼָĿ¼ϣ̼ƷOMP
ΪӦñ϶ΪΥΪ

ЧΪʹOMPǷ°ʻûжԣţOMP
ʱڼ۸òƷӶ߹թ

Ч߽ͣţǷ߹թһҪжϱ׼
Ϊ ţǷʳƷǩرʳƷɷ֣ĳɷʵ
ʲϣô͹թʾĿǰţOMP
յĽȻֻӪɷֽϸߣδ֪OMP°ʵ
ĳ̶ֳ˵ǰߵ֪ȨȨ

ţĹٷվϣ߿OMPΪ ؼƷ
ƼƷȷ OMPзḻĸƣֱ
ڹͷϸӶʹסʣﵽֱӹ
ȵá

ԴˣЧΪĿǰOMPѱרָ° ţ
ƷıǩϲûнܷΧѾթ

Ч˵ ʳƷǩʳƷĽռʳƷװķ
֮һ һйȴǳ̼ڱǩϿ佱ԼʳƷ
ȴûʵطӳƷĹܺʡ

Ҳָţ˾ٹ棬թɡӱʾţ
˾ǰʱһֱ˵OMPй Ӫ뷢չġţҵ
˾оĳɹֱʾǴTATUA˾ļǰìܣ
ƭߵɡ

̽

ְܽγɼܡ֮ء

ӼĿ¼ûгֵʣ̼κγɷֶǲģ
ӣӦΥЧ߼ߣҹδ䲼ʳƷȫ
ţ OMPա¼Ӻ̶ܴ͹ҹʳƷϵ©

Ч˵ ǹûĿ¼ȷָӵʣ
ӣʹӵĳɷǰȫġʾʵ飬
ֻҪǹûָӼӳɷ֣ʹûֹ̼ҲӦ
ӡ

ʳƷκγɷֶںϷΪôҸӼָĿ
¼ʲôأЧΪҹ ʳƷȫȱʧҹʳƷ
ϵĸģ

谷OMPƷƵƵֵӼ⣬ìͷȫ
׼̼ƺҲʧʣϾ̼ҵֲԣǱʹȻ
ңֻһҵĸΪڿ˵Ǹ̼ҵµɥ
֡ǣʱΪᣬ谷OMPʱ䣬Ʒҵ
¶ȴͬʱָʳƷӼʵƶΪżȻ

¼һΪ͹ԳǱǡҹʳƷȫ
첻Ӳˡ

ʳƷȫļϣҹĹŹܡʦ
ƽʦһѪָ ŵְܽγɼܵĿհ
شʳƷӼ⣬ʼಿŷֵ⻹Ҫ϶
ֲַܵƺɼͺ󡣡

֮ǰ ʳƷȫݰǷֲӲ
أƽΪòݰѾ󣬵ΪΪţ
ܲŹϵ˳ϣȻû޸ġ

ЧΪ ʼܾ֮˹עţOMP¼һ
淴ӳҹʳƷӼӡʹҵڶԱӼ
ָĿ¼ʶҹ ʳƷȫճ̨

ţ걨OMPº

ţ¸߶˲ƷOMPգδʼܾ
OMPɷݺ󣬱ţĹɼһȿһɡ

ߵ鷢֣ţɼµͬʱţڲʧȥг
ڵ֪ţڿܺ°ʺ󣬷׷ױʾٹòƷ

ԴˣЧΪʹOMPձ϶Ϊ޺ʣţҲ
ҵºάȨ ΪһʼûаչӼָ׼
ӳɷ֡

ЧָֻҪţܹʱȴʩOMP¼
ţ ţˮһȥء飬ţӦΪOMPԭе 
֤ʱ걨ùɡ

ţҪƷвžOMPʵ鱨棬OMPķ
ӦȷԡOMPȷʵûΣţӦŵOMP
Ӽӳɷ֣ζɫйٵȸԹ涨

ЧΪţƷ° Ѿ֤䲡
ţֱйأֻթ⡣ָһOMP
ʼֵܾɣţԴ˻Ӧթ⡣

(XYS20090213)

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ţOMPΣ

   
ʱ2009-02-14     	

谷شδԶȥţٴݡţ̵סУ
һΪ߶OMP̡

һ¼Դڹලܾ֣³ƹʼܾ֣
һֽ22գʼܾɹලַҪ
ţ˾ֹOMPIGF-1ʣǿΪʣ
зɷĹ涨

ţġţOMPո߶̵Ҳ߽⣬
֮ǲƷ¼ܺٻءһҵר͸¶Ŀǰţ۶
ռ۶֮һңòȷ˵佫


ݱ˽⣬ţղƷѾʼ¼ܣشţܷ
ţء

˭գ

ʼܾڹбʾҵΪOMPIGF-1ǰȫģ
ҵշֱṩزϣǷʹ
OMPIGF-1ľ

OMPƷ2006󣬶°ɾͳϣ֮ǰΪ
ҵЭʿιʼֹܾʾ˹ٷԸòƷ
δ֪յĵǡ

ǶţţOMPĹע211գʼܾйظ
˸ʾĿǰڶʳƷӼʹýȫ١ţ
ţеOMPʵİȫԣʼܾڻͬйزſչо
ʵʽԹ

ţOMPƷܴڵǱڷգɵǴ˷ӡ
2007326գ䴴˿վġԡס塷
䡰ţ̵סϷģרҵĽǶţ
ӵOMPʵIGF-1ɴ෽ע

У㶫ҵЭҲУվϷҵͬ
531ʼתйţţ̵׵£У
ݼߴӹ㶫ҵЭ˽⣬йطϲ·߶ҵЭʩѹҪ
ɾйţյ£ѹ㶫ҵЭὫƪתر
´ϳ¡ɴ˸ЭţҲˡӡ

ΪҵЭḱ᳤ޣͨȥ˽ţ
ʵԺ֤ݲϣ㶫ҵЭרϵ鷴ӳ
⣬м⵽ţ෽ѹ谭

ʵϣţкIGF-1°㶫ҵЭо
20076³㶫ҵЭ㶫ʡԼ㶫ʡʳƷҩƷල֡
ʡල֡㶫ʡ㶫ʡ̾֡㶫ʡũҵϽ
ţţǵķӳ淴ӳϡͬ7£Э
ҲύڶţOMPţӼصIGF-1ϷԿչ
ʾ

㶫ҵЭᲢûеĻظڶŵѹ㶫
ҵЭͣ˽ٷţŬûзղƷ
ĵ顣

ҵҵר͸¶ţڱмؼأ
һǶλרʼֵܾزŵľٱɹҪ
ţԾٱݸ˵Ҫţγɱϱ͹ʼ
֣ţײڹʼֶܾʳƷҵӼٵǹϡ˶
ؼһʹ¼

⣬ݸҵר͸¶ڹʼֹ̨ܾǰҲ200811
׵ʱжλרҺͲʿƻԺӳţţ 
IGF-1°⣬ǿǵ谷¼Զδ˽ᣬĴ˾ٻٴθҵ
û飬ǽйⷴӳ붽顣

ҿOMPɴ

˽⣬OMPOsteoblast Milk ProteinΪţ̵ס
ţƷзTATUA˾зġOMPţΪԭϣ
֬Ĥ˵ȹƳɵţ̼Ե׻ҪɷΪס
øȡţڸĹٷظбʾ

ѧ˷ΪţվϹOMPݣ
ⶼڶоһֵʡࣩȵӣIGF-1
ȫǺϡţ2006ύһרҲڡܴٽԸƵա
ţƷIGF-1

IGF-1Insulin-like Growth FactorsΪࣩȵ
ӡصһ֡IGF-1ܹзڣ弸ϸ
ܲáIGF-1ְ֢

IGF-1°飬ţԴΨֱ֮ţڸĹٷظ
ʾ⣬OMPţIGF-1ĺͨţһ

ڱ߻õġţר˵顷ȴȷʾ
ڰɱ򳬸˲ʱţһIGF-1
ͨţIGF-1ܹٽԸ
ա

ڡţ̵׵̼ר빫˵У
ţȷʾOMPĹ淶ΪGFCҪɷΪȵسɳӣIGF-1
IGF-2תӣTGF-1TGF-2

ţı

йҵЭ᳣ޱʾʼܾѾ·
ţϵвƷӦ¼ܡٻءͣҵӦû⡣

211գֶ곬з֣ţ23ռ˺
OMPȻۡ212գָȳ
Ѿ¼ղƷԭδ͸¶

ڲƷǷ¼ܣţȷʾɹʼʵؿıȷָ
ܹ֤OMPţ̲ƷȫԺδIGF-1ţҲʾ
Ŀǰ⣬ϢԳ£۶ղ⡱

޽ܣһţҲIGF-1ܵͣŨȴԼΪ
4ng/ml㶼սڣӰҲ΢΢

ڡţר˵顷УţᵽղƷÿ100
IGF-1Ϊ5.65-16.8mgһţ̵򱶡

δ

IGF-1°ţеţٴѩϼ˪

ǰȥףţ2008ƱԤƣԤ2008ԼΪ
9Ԫ2008ϰ꾻Ϊ5.83Ԫ2008ϰ꾭Ӫ
ҵ14ڶԪ

ҿ𲢲ֹڴˡĦʿоԤ⣬谷¼
ĲƷٻغעֿ棬ţΪ˽֧20Ԫĳɱ߼һ
ţȥȫ𳬹30Ԫ

ͳʾ20063µףţƳOMPOMPţ̣
۸ţͨҺ̵2

2007꣬OMPƷռ߶Ʒг߳ɵгݶ2008б
֪ţӪҵԴţ̲Ʒ߶ƷOMPƷȡ

֤ȯʦָѳΪţġϵͳOMP¼Ӱ죬
ţɼ11ձеһȳ22%ọ̈̄ɼµ12.48%
10.1Ԫ

Ŵ֤ȯʦڽܡʱ߲ɷʱ򱶸ź谷¼
ţȫšѩϼ˪ɼ۵ıкܴӳƽ֤
ȯʦָ¼ţӰޣƷƵӰϴ󡣶ڿ
ۼµ12гֿ⡣

ݼ˽⣬ĿǰƷʼڱ¼ܣƷȫ¼ܽ
֮ζҪӯƷսһ

ҵҵרԤƣĿǰţղƷÿĲԼΪ16ң
Լռţ۶֮һҡ

ҵʦԤƣţ2008۶ԼΪ230Ԫ
֮һ㣬յ۶40Ԫ

谷¼ţгݶĿǰջָ70%ңȻҪԺܴ
ѹ

űţòƷ½¼ܣ֮ȫأʱţ
ܵĴ谷¼ڲƷǷ¼ܣţٷûи
ȷ˵

֮ǰʽţһȴţعȨʣţ
Ŭ»⣬һ٣ʳƷӼٴУţٴ
ͷܷء

ţﻹܺȳʲô

  

Ե½ʯġ谷оеOMPţﻹܺȳ
ʲôǲ֪

ţOMPйزѾˣǷȫйز
о212գʿ߱ߡ

ʼֻܾӦOMPйرҲͬƣʼܾй
˱ʾĿǰڶʳƷӼʹýȫ١ţ
ţеOMPʵİȫԣʼܾڻͬйزſչо
ʵʽԹ

ݱ˽⣬OMPڹʳƷӼĿ¼ڡȴ
ӵ档

ʳƷӼĿ¼ƶйءʿƣֻʳƷҵ
ʳƷейʵϱϣȻ󾭹ʳƷӼίԱ϶
ʲſԱʳƷӼʹáҪҵ걨

ôһ˵ҵϱĻʳƷ
пܲʳƷӼ

ĳҵ²Ʒзʿ߼ߣڵгҵ£
ʳƷҵܲסߣȿǿζΪֱ۵ģ߸
ٿԸоġôҵ󻯵ʹ£ʳƷʲô
ǲ

ȻҸʳƷȫĸŻҵмܡǹʵʳ
Ʒȫֶμܵ£ԭϡѵĸҪЭȷ
ʵ̫סΪʼ첿ŲÿƷһһȥ飬ʳƷҵ
ûϱĶڲƷеҲ̫һһȥ

Կ϶ǣţӵOMPزϣȻѾţ
ʿʾ䰲ȫо

Ҳ˵OMPܱܲ϶ΪʳƷӼڻȷ

ţȳģпǹزڡоеOMPʡ

˭١йţ

ٵţĲţԼ

ţѾö꣬OMPҲһֱڡȻţڷй
гƣOMPǰȫġԴˣûжԣҲ˵

׷Ƕ˵ţԴԼ򵥵߼
ǣţOMPֶѾܶˡͻȻ
һ죬ҵйزűʾİȫԻҪоǶ˵ţԼ
Լ

ȻţOMP谷谷¼֮
Ըϸ᲻Ϊڶ谷ˣţ
ɵġ

Ȼҵ֮⣬ǲӦһ߹ȥԼҵΪ
ȥ֤ҵȶĹȥơ

ʼƼ֮ĩ谷¼ˣţOMP粨Ҳһ

ߴӹ㶫ҵЭ޴˽⵽2007ʱǾͷ
ʱҵʳƷӼĿ¼ﲢûOMPʡʱǾԹ㶫ҵЭ
йز˱棬鲻֮

ʵϣ㹻Ĺ㹻Ĳȥҵʼ졢
šصĹ涨ڼֶεͺ⣬ʳƷ
ȫġ©

˵Ѷ࣬ôйţ֣ǡܡ
ô򵥡

(XYS20090213)

˿(www.xys.org)(xys3.dxiong.com)(www.xysforum.org)(xys2.dropin.org)

ţOMPս

ߣ
0090214վù۲챨

Ա񼫸θеţƵĺĸ߶˲Ʒ͡㡱
OMPţ̣ѾһʳƷȫơ

OMPţ֮ţҪΪţҺ̵̬
йۣʵ漰ţ߶ţ̵սOMPʲô
սĽ

ʼ

˶ӵһʼ

211磬ܶýյһ winterspringmoon@163.com
ʼݾǴռ˵Ĺʼܾ22ɹ
ල֣ơɹʼ֡Ĺɹʼ
ţֹţOMPʡ

212ţŸܲáŷԶһݳ22ҳ
WORDļǹţOMPţ̵ĿƼϣĩβָɹ
ڽ1¸ʼֵܾġں˲ţţйı桷
ʼຯ[2009]7ţȫġʼܾ22յķ ʼ
ຯ[2009]7šļ

ɹʼֵ⺯˴ιٷĽԴڹʼֽܾӵţ
ţ̲Ʒľٱ

14գɹʼյʼܾ֡ڵ鴦ţţ̲
ƷٱĺձܾƼרϵ֯˺˲С飻1 5գ
˲С鸰ţ˾ʵغ˲飬Ҫţ˾ļҪṩزϣ
ܾƼרƳ8˲ϸ˵ţOMPţй
OMPȫԽ˵ɹʼֵĺƣ˲С
ֳûзIGF-1ԭϡ

谷¼󣬹ٷйҵʳƷȫľᵽǰδеĸ
ȡ谷¼䡢ٷİȫԶӽ
ƣɣܲȲȡʩͣҵΪǰ
ºӡһλҵʿп

ɰ֮

2005꣬ţմţˮ߶Һ̬гΪзĵһ
ˡݳƣΪ˸ıҺ̬΢ľͬʱ㲿ָ
Ⱥ

ҵʿ䣬ƷнͿʼȲ

20063µףOMPţ̸ߵСţʱ뷨֮һǣƷ
ֵķʽһ̺ϸгOMP縺һǣո߶˶λһ
߶˵

OMPţ𣬾һֱţġţ̵OMPһ߿Ƽ
ΪԴ͹ţյļơ

ţĹٷվϣOMPţʱϣɹҹ
Ӫ뷢չ⡢ţҵзġţ̵ףOMPǿܶ
ĿڹϢʽͨרļϵһOMPƷ
ţOMPţ̡ҲʽƳ

ĿǰţϵѾΪţ̡OMPţ̡̡֬л
̡

OMPţ߶Һ̬Һ̵̬۴̼ûҵƣ
ţϵռڸ߶Һ̬гһϣֹ߹ 70%
ңһ30-35Ԫңţ2007213
Ԫ̵ͨʴԼ2%-3%߶Һ̬ 10%ϣϵ
ʸߡ

ţOMPţҵı̬൱͵212գţڸ
˾йţҵ޹˾02319.HKڹгƣգOMPţ
̡һȽռ˾ۺӪҵԼ2%۶δ棩

ţϵи߿Ƽ֧ŵ㡪OMPܿ
ʸ֮ġ

OMPţһ20073£˿ʼɣΪϸû
Сţ̵סֶOMPţ˾Ϊţۼ۶
һʵɷӦһֽIGF1ȵӣ
ȵعܵļأںȴˡOMPţ̣ӻ֢ķա

ѧ˷ǵʱɷ粨ʼٸ֮һĲԱ
ŵʱýܴƪ£3µ׫дġԡס塷4
³Ĳġţţеġţ̵סʲôɹ
ʡҵЭ졢Գơҽ滰Ϸҵ20075µ׿ʼ½
תһЩţţ̵¡

Щƽ䲩мأƪ
յűҳӶҲˣʱι㶫ʡҵЭḱ᳤
ڵġţţ¼¼л䣬ѹվתص
ƪOMPţ̵ɾʱ㶫ʡҵЭỹйز
ύˡţOMPţIGF-1ϷԿչʾ
ûл

ԡ

ʱסһΣ䡢ٷҪţиоݵ˵

ԡʼֽܾͣţOMPʡı211磬
ţӦƣOMPȫܵFDAȹȨϿɣΪ
OMPְ֢IGF-1ֲһʣOMPţδIGF-1

һӦȴҵࡰζ塱ɵ㡣

ǰOMPǹзţ11յǿOMP
ǹоʹöţ̼ԵMBPţƷз
TATUA˾оġǣOMPţ̸ʱţȴƣ
OMPţţҹӪ뷢չĹͬзר

ܶɣţδOMPţIGF-1ôרOMPţ̣
ţѾרġһҺ̡̬ר200610003551.9Ǻֹϵ
һҺ̡̬Ҫɷ֮һIGF-1

212ţŷԶһ22ҳWORDļ
ͼӼOMP⡣

Уͨմһʵҵļţ֤Լ
δIGF-1

ţܴܲӮⳡ̣ؼйźʱOMPиȷ
жһλڴҵӪʿ˵

OMP¼ܶţӰ죬ţٷֳĬţŷ
Զ212ֻǼ򵥱ʾĿǰΪֹţδӵκ
¼ܡ֪ͣͨճ 

(XYS20090213)

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רΪOMPţ̲Σ

    »213յ Խעɹţҵţɷ
޹˾OMPġաţǷڰȫ⣬רҸݶOMP
Դա鱨ԼͬƷɺ͹ʹ
ΪĿǰгϸòƷûнΣOMPҹй
׼ʹõʳƷԭϣţ˾ڲʹOMPû׼Υ
ˡʳƷйع涨

    ͬҵϢũҵ񲿡ܾ֡ʼܾ֯
ӪʳƷũҵȷרҶţ˾ʹõOMPʳðȫԽ
֡

    ݳƣOMPţ˾ƷƣϺͳ԰ʳƷ޹˾
ڣΪƷԭʹáOMPţ̾֬Ĥ˵ȷõţ
̵֣ҪɷΪסøƷ߱ʳƷȫ
ߵİȫ֤

    OMPҹй׼ʹõʳƷԭϡݡʳƷ
Ĺ涨ûй׼ĲƷӦ׼ţ˾ڲ
ʹOMPû׼ԿƷܣΥˡʳƷ
йع涨

    ݽܣţ˾ѾйִŵֹͣڲƷOMP
ʾշɹ涨롣йִܲŽһԸҵΥΪ


(XYS20090213)

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OMPMBP˵
MBPЧδ㷺Ͽɡ

20090213ձ

Ѷκ꣩ţԡOMPMBPһŷʹ
ļţ̵ס˵רɡרҷ䲩ϱʾ
ţ˵ţǰOMPţ̵йרе˵ȫ
ӵǼţ̵ MBPҲʲôرĺô

ݷӽܣйOMPİɡС
IGF-1ȫֲͬͬĵʣɡ
ˣOMPǰIGF-1һƣͬһʡ

IGF-1弸ϸϸܲãܹ
зڵļأһţУϵͣ¶ᱻ
ʹְ֢

һOMPMBPΪһֵʻڷҲڷ
һ󲿷бɰᣬԱֱ
ãҽѧֻмƪƿڷţ̵ӹ
ȣЩоձĳţ̹˾ģΪƾ

8ʹϵţ棬䷢˱ʾ칫˾ʱûµ
̬ע⵽ţǰյУֻǿMBPİȫԵõ
FDAȹʻϿɣûǿõõϿɣˣսȷOMP
BMP֤ղڰȫ⣬漰

(XYS20090213)

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ֳʱ¼ ѧ߳ţ˵

:½ 
2009213Ͷ

մ谷̷¼лţµOMPţֱOMP
°ԴˣţϺֹ˾ʾղƷѾͼ죬Ŀ
ǰϺҲû22պţ̡ʼֱʾδõ
֪ͨвֳѽղƷʱ¼ܡ

ֳҹ¼

1ʱڲ㳡ҵմţ̡֬
лƷ֡ɫװOMPӰԱ߼ߣ
11ǽӵ֪ͨƣҪOMPϵвƷȫ

󣬲йʿ֤ʵϢʾ
˾ҹȡ¼ܴʩ4ʱOMPϵУ
Ʒʱ¼ˡ

ϴ󲿷ֳлδڼָ·꿴ţOMP
ţۡڸòƷϱעOMP 8mgϡװ
λϻдšOMPһţеȻԵףѧʵ֤
OMPƹϳɴлǿܶȣٽӣʹ


ţڼָĴԱ˵OMP̼۸Уһֱ۵ò
δ˵OMPţ̱ͣϢĿǰûнӵ¼֪ͨҲûнӵ
ߵѯͶߡ

δ22ԺƷ

ڲƷڲֳʱ¼ܣţϺֹ˾Ͷ߲йʿδԷ
ϡ߼ߣյĲֲƷѾּ⡣

ʿʾ⼸û³OMPƷϺ
йʿҲʾΪϵţǳ̣ڱȽϳԳ
û22ԺĲƷ

Ϣƣ𣬱ҳѿʼOMPţ˻
ţϺֹ˾ʿʾûյ˻֪ͨ

ͼϵţܹ˾Ϻֹ˾ϵˡ绰æ
״̬

Ŀǰ޽֪ͨ

ղƷǷ⣿

죬ߴʼֵõĴǣĿǰϺ۵ţ̣
زϺݹʼܾعԭţӦɹ
صʼಿŽмܡĿǰϺҲûеõκιţ̽۵ͨ
֪

ĿǰʼܾڻͬйزſչоţţеOMP
ʵİȫԡ

ѧ߼ţ˵

OMPͻȻڷ˼⣬ǷмصIGF-1йءרָ
OMPصIGF-1ܴٽϸ°ԡ

Դˣţ11ջӦƣOMPIGF-1OMPţΪԭϣ֬Ĥ
˵ȹƳɵţ̼Ե׻ҪɷΪסøȡ
ţƷзоģŷޡձ
ȵʹöļţ̵ףձ֮Ϊ MBP

һվOMPɵѧ߷ԼĲַ
һƪٽţOMPţ̵Ļԡ£ţ˵ѡΪ
ţǰṩOMPţ̵Լصר˵϶OMPIGF-1
ҪɷIGF-1˵ţܼĸ˷
ȷ˵IGF-1OMPҪɷ֡ôʱһ꣬OMPҪɷַ
޴ı仯ȫһأָţǰ˵ѣ
˵ѡ

(XYS20090213)

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ݲֳнƾСƱ˻

ߣӱ˼
2009-02-13ձ

գ߷ֹݲٳţ̾ڴţƷƵͨţ̣
еOMPţ̾ںܶ೬Сʧ١ţڸ۽棬
IGF-1 ĺͨţһȺйزŶԲƷȫԵĻظ
ҵƵƵ粨ʲôţ̰ȫ⣬߾ʹר
ѧ˷Ӻҵʿ

ֳ۵

գ¼OMPţ̵ĳзΧ󣬶ֳн˻
̰ټ֮󣬺ֶ೬OMPţ̣Ԫ︽ĺ
೬УԱʾֻҪСƱͿ˻ѿֻ˲
л㳡֮ԱʾOMPţ̿˻Ʒֵգ
ҪСƱͻװáڹ԰ǰİټѳеţ̻ܣû
OMPţ̣Ʒ̨ۡС˵˿ͿƾСƱ
ƷѿҪϵҡ

ָҺʤѵȳزƷбʾĿǰû
Ӧ̻ŵ֪ͨԱܣţƵƵֳ粨ԭȰڷţ̵
𽥱С̺ʳƳɵϾλֽ·ʤѳУ߿
ţ̻ɵĿռѻɰڷϡ

̷۸̼

ڶӤ̷ۣռ߷üָټѡ֮ҡʤ
ѵȶҳУûзжӤ̷¼ܡָټѳбʾ
ĿǰûйŶԶ̲ƷİȫɣԲԲƷ
¼ܡҳҲʾ̷ÿζṩϸ񱨸棬
ԲԲƷ¼ܡ

߶Իӣ

OMPӼ ˾Υ

רעղƷʿ֮һѧ˷ӡ
ţOMPIGF-1ͨţһ˵˵֮ǰţĹ
˵OMPIGF-1ͷΪʲôҪô?Ҿ
ǳOMPȥġɹ

ţʲôӼǰȫ?ӱʾӼǱҹʳƷ
Ӽϲӣ򲻹ʲôӡڹҵû
ģټӾΥڷǷΪЩǷǷĲƷֱʾ
ӼʳðȫҪͨʵ֤

գţҵڶµ3.17%ţڸ۽
ţ̵İȫԣֱʾOMP̵ֻռ2%˾Ŀǰйصϵ
Ⱥظ

(XYS20090213)

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Ӫѧר

޷ɽ ʵϰ    
20090213

ʼֽܾͣţһ¾ý¶йע
ڲɷ˽⵽ոոսгʱӪѧרҾ
յİȫԡ

רǰ

2006°꣬пЭʳƷȫ֯ڹרҽר̸
̸ϣһλӪרţպеġOMP
ʲôʣҵںܶмҶ֪Ҳû˵ʵİȫҲûȨ
ٴ顢ȡ

λרڵĹһЩӪרָOMPIGF-1ֲͬ
ʣIGF-1һּأǴͳʳƷԭϣҲδʳƷӼʹñ׼
ܹδOMPİȫۣɷ֡Ҳӡ

°ʼαʿӣΪţ
OMPһֽIGF-1ʣйIGF-1ͻᳬ
Χܻͨܰ͡θ˿յڣķվͻӺܶ౶
Ϣ22պѲOMP

ţвκ

ҽһԺӪŸΪȻʳвӦʡ
OMPһ嵰ףţбѾУţ
嵰ټţУ京ƱشӣֳɱӪǷܱȫ
գĿǰ޶ۡ

ŸΪĿǰгϵţ޿̡ţ̡̡
ţ̡̡֬߸̡ƬҺ̷̡̬͡۵ȡţ˵
еĸӪѾܾ⣬ĳһֻʣƱػ
ƻ־⡣гϴڸֿζţ̣εĳҲõ
㾫ʳɷֽеζƱػΣˣ
ȻʳƷʵΪӦýͣ

ճúţȫ֬ţ

죬߷˹мҴͳУֳOMPţ¼ܣ
ѯԭԱƲ֪ʲôԭ򡣼߿в֪
ա

һλŮʿǵضԼ˵Լͼ˺Ѿһˣ
֪ôʱ䣬׻᲻кԺѡţأ

ŸܣĿǰȨٴ顢ȣǷΣ
ΣжĿǰ޶ۡ

רָţ̵ӪΪḻţеһЩ΢
ɷ֡Ӫѧҽ飬һӦ200250ˣúọ̈̄֬
̺͸ƷźȣעⲻҪո̡⣬۶ͯ
ˣضŨȸ߷ڣʱϳɴлʢ⡢
Ѹ٣ͯţ̵ʱ˯ǰ

(XYS20090213)

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6вֳ¼ţţ

2009-02-13ײƾ

ţ""¼ ֳѽ˻

11ȫұ˹ʼֽܾͣţţOMPʺ
ý塢ߺгĹ㷺עմӱлϤָ
OMPţȫ¼ܣͣţ̵Ľ

ָŵOMPţѾȫ¼ܡָй
ŵظ˸߼ߣǼָܲ´֪ͨʾûе
֮ǰۡλ˸߼ߣΪ22֮ǰ֮
OMPţ̶ƾСƱڷ̨˻ֻĿˣвˡ

ӱֶϤЩеOMPţ
ֶۡ곬бʾװãڿ԰˻ÿվ
ţ

죺ţ Կʼ˻

챨ţţ̺Ͷ̷粨˾з
ŵӵ쿪ʼԹ˵Ϻּܼܲұ˵
̽ÿ췢߷ʹøù˾ĲƷ߷ø
з֣ѶԶ̺¹˻

͡ذٳгƣ5㣬ûнӵƷƳһʼ첿
ŵ¹֪ͨ

ԳƷƷ¹û⡢ṩ̷
СƱĹ˿ͣɳзǮ˻ԹƷѿĹ˿еǼǡ
7㣬óѽʮ̷۵˻ָҲʼ
СƱ̷ûĹ˿͵Ǽǣȴ˵쳿

ݷ еȴȨ

пǵߵİȫĿǰ󲿷ŵ궼Ѷ
ţݴ洦ʱۡڵȴйزŵȨ˵϶
ڰȫۡ

ҳȻûг񣬵չλáԱ
ߣǰƷλãкܶ˿͹
ȥһ۾ֻܿһ䣬ϸңһҵõ죬
ͨý֪ջȥóи˱ʾ
Ҳڵȴйزŵ϶㽭ߣ

ֳȻ¼ţţ

գ߾ͻ۵22ǰţţһ
⣬ѯֶ곬еظˣԷ߼ߣĿǰҲ
йעһ⣬ʱû߶ԴͶߣڵĽ
õ̻ʼ첿ŵ¼֪ͨ϶ڵһʱִС

ҲͬĴ𸴣ҲгȻţţ¼ܣ
ѯԭʱԱȴر˵ֻʱȱϾͻᲹ롣

Ʒ۵Ļǰע⵽˽⵽йʱ
ۡţǴƷƣǴǰһOMPգںȻǲȣ
Ҳò׼⡣ʾ뾡˽ʵŮ
ʿʾ谷¼úӸĺȼ۸Ϲţ̣һһУ
û뵽۸ߵĲƷҲ⡣ʾ֮ǰʱṺ
Ʒţ̡

Ͼ ͣ

ϾֳУ߿ţڻϣƳ˴ռ
ݺܴǣյȴô磬ֶ
ж׵㣬ţ10Ӷûκۡÿ춼кţ̵
ϰߣ߼ߣﲻȣһ꼶ĶÿҲȣӻڳ
壬ǿǵӪ⣬谷¼ع󣬻Ǽţֻ̣
ٶ̣Ǿջǽ䡣ڳ˵Լ
֪òţ̣ԭü谷ƷǼ۸˵ģ
һֱԸߵ̵֣û뵽Ҳ飬ǲĶ
кҶӳˡ

ߴһҴ˽⵽ĿǰزŻû·ţ¼
֪ͨΪ˱лֹͣյִۡ챨

ɽ̫ԭغúͻѿʼ¼

磬ʡλһ·غóпţĹ
Աţ̣Ǹսӵ֪ܲͨҪ22ǰĺOMP
ɷֵţȫ¼ܡйظ˸߼ߣȻɹ
ಿŵļʾЩεղкɷ֡Ŷ߸
̬ȣǾȽţȫ¼ܣֻš
ܣţǷкȴȷλڸֵĻ
УţҲӰйظ˳ƣϢ󣬳
ڵһʱȫ¼ܡ

ʡǳϵֶ곬Уջۡйظ
˸߼ߣŶйƽȶԴԭǲ׽Ʒ¼ܡ
ȷƷ⣬ڽӵйزŵ֪ͨһ
Ʒ¼ֳܲ߻½ţ̷
ﳵһλ˵ϵϢҲˣӦùϵ!

˴ͳ⣬С͵Ҳۣʡ
Ƕұ귢֣Ȼڷ۵λá·һҽ𻢱
ĵ곤߼ߣӽǰڣ׷ѵҪյһֱ
յġOMP ¼곤Եúܲ⣬ôĶô
°?

ɽ𻢱޹˾Ʒһλ˵й
ıѾϤֻҪܲҪ¼ܣһϡʡ
̾Ҳʾڵȹֵܾġͷļɽ

(XYS20090213)

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յĸ߼۾OMP

ߣκӢ
20090213Ϻ̱

ȥꡰ谷¼йҵĺշţOMP
ΣܰѸոָĴԭΡʼֵܾһ⹫
ڽͣţղƷͬʱҲһҵ籩

ʼֵܾ˵ţ߶ƷӵOMPǷ
ȴŵļ⡣Ŀǰ֤ţ˾ºѴⳡΣ
аȻۼΪΣҵǷһ

йؼڣOMPʲô

ţʾOMPţ̵ףһţ
ȻԵףܹƹϳɴлǿܶȣٽӣʹ
ţ˾ܲȺʾǸù˾зר
ƷרҷΪOMPʵϺIGF1Ӧͬһʡ
ѧоIGF1Ӱ֢ʡҲǹΪĵ⡣
ʼܾڹͬʱOMPIGF1ֽз

˵OMPȿţзרƷҲǹƵIGF
1ǰߣʼܾǿģ䰲ȫδȷ涨
ߣţһشڰȫΣĻ˵ţ
ҵٴۡ

֮ĵֿԣţ˵211ţ
ƣOMPIGF1ȫһʡOMPǹоʹöţ
̼ԵMBPMilk Basic Protein䰲ȫܵFDAȹȨ
Ͽɡ¶ţOMPԭϾTATUA˾ڡTATUA
˾ţȡȫЩҲ20ʷ

ֻصһϤﾳ緢ҽҩ²
Ʒ¼ͷһҩǸҩʾͳҩȻܲ
˲εļۡţ˵ù˾۸һţ̹գ
ؾҲڴˡǣOMPǴӹ MBP
ôţǰġзܸڣҲҪۿۡ
֮νOMPţһгӪԣͨʣз
г֣Ӷȡֵĸ߶󡪡бƣյ
ߴ100

ĻţһɣղƷǷ
ʵˣгӪʿ䰸ղƷ񷴵
ţOMPһֿ°Ӽֻţ˾Ĺ
ӪŽܿͻǺߣ빫Σ
ţԵԼǼĴ˻

ŵ˵ţȹҵ֮ӹ谷ǹںͼ
Ŷԡҵһֿݡ򣬰谷¼ţ
ֱ֣ҵñ乬һ˼άռϷ磺Ʒ
ȫ£йҵΪ׸ĸˣ¹
㣬ҵ÷˼ĵĿռͻᡣ

ڽ죬бҪǿһ㣺ݲݡҵùڵ
֮ġеƷƲֻǷİһг͸
׳ʿľģշʹֻϵȫй
ҵӭ졣

(XYS20090213)

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˭ڡݺţ

ߣС

¡ţ

һֱԡ¡ţ谷ֱ֮ýרץס
Сӣγţĸ߶˲Ʒҵеţ̡
ա°ʡOMP

2009212աй֤ȯԡţա
°½ʼĩ½˵ǰгţҵ
02319.HKƷOMPʶ°вٱƣ
ʼܾ22ɹලַҪþţ
˾ֹաţOMPʡ 

˽⣬ʼܾݹĿǰҹδOMP
ȫȷ涨IGF-1ʲǴͳʳƷԭϣҲδʳƷӼʹ
׼ΪʣзɷĹ涨 ἰ 
IGF-1insulin-like growth factorsȵӣΪһּ
൰ףרҳIGF-1˫ԣܹʹϸҲܴٽ
ϸ°ԡ 

ǰѧ߷ţɣΪӵOMPͬ
IGF-1ӦͬһʣIGF-1Ӱ֢ʡ 

ţҵ11ƣOMPIGF-1ȫһʣɹʼ
ʵؿıȷָܹ֤OMPţ̲ƷȫԺδ
IGF-1 

ʼܾݹĿǰҹδOMPİȫ
ȷ涨IGF-1ʲǴͳʳƷԭϣҲδʳƷӼʹñ׼
ΪʣзɷĹ涨ţ˾ֹ
ʣ֪ͨţ˾ҵΪOMPIGF-1ǰȫģҵ
ֱṩزϣǷʹOMP
IGF-1ľ

˴ǹٷ״ζţġOMPб̬

ԭǰѼ

˽⣬20075312007615ڼ䣬޵ҵרͨ
ҵ˶ƪţOMPIGF-1صºͷ޻䣬
ʱҵרʵķʽۣ߷ʱ,
250 

˽⣬㶫ʡҵЭ㶫ʡʳƷҩƷල֡㶫ʡ
ල֡㶫ʡ㶫ʡ̾֡㶫ʡũҵȲŷţ
ţǵķӳ淴ӳţʹӼ 

211գOMPʼֽܾͣһ±ţ
˾Դ˽˳塣ù˾ļƣOMPȫԻϿɣOMP
IGF-1ȫһʡ 

ΪIGF-1Ӱ֢ʡΪIGF-1һּأ
غߣܴĸá 

Դ˵ײƾһOMPܶкɵѧ߷
е绰ߡ˵ţ˾רʱĲϿOMP
ĴСжٸIGF-1һģһġ
ֵͬһģһģǲܵġ͸¶
20073Ϳʼע£һЩ½в 

ţOMPרϣҲʡл񹲺͹
֪ʶȨվ鵽ţֻйIGT-1ר룬רժҪ
ʾṩҺ̬̣ݵ֣ţ 50-90IGF-1 
0.25-0.50黯0.1-0.3ˮ8.20-49.6ͨţIGF-1
ܹٽԸƵգͬʱţӪ
ֵƱлܱ֣ƻ㷺ڶͯꡢ
ˡиԼڹǽĸεȺͬʱԸ
ղȺҲһõġ

գţ˾ʾɹʼʵؿıȷָܹ֤
OMPţ̲ƷȫԺδIGF-1һͨӣһַӣ
أ

ѧﻹţ˵ѣ

ѧ߷ڲдţOMPݣIGF-1
ȫǺϡţ2006ύһרҲڡܴٽԸƵա
ţƷIGF-1дһţҲIGF-1ʹ
ȫʧܵͣŨԼΪ4ng/mlţר100
ӵIGF-1ߴ5.65~16.8mgΪһţ̵򱶡ˣͺֵ
ߵˣְ֢ķջӡ

ţ̽۶ϣ1ţСȻ鵰ס2ţ
ġζ㡢Ũ㾫ġ3OMP
IGF-1ȫǺϣաеOMPʵֻǻ˸ơ 

20083£ţȥѧݽʱ̸һǡƷƾ͵ø
Ρ̷֮¼֤ţġƷƸΡ˵
ΣתΪţΣǳ20081018գţйҵ
ֲ¼ѧԺͬѧдΪйҵ﷣ξȡ, 
2008йҵᡰʹֵҵֳֵ̳ţҥ˵
ǰý屨˵ţΣǱģţ˾
ûгֲΣ

(XYS20090213)

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OMP֪Ȩ

ߣ⺼
2009-02-13ִ

11,ýϳ֡ʼֽܾͣţաOMPϢ,
עʼܾӦ,ʼܾͬйزоţţ
OMPʵİȫ,оʵʽ212ա


ǳź,ٷ״ζţġOMPб̬Ϣ,һܺý
ġһ¹ذʳƷȫҪϢ,ڹʼܾ22ɹʼ
ַʱ,Ϊûмʱ¶һ
ݣΪûмʱڷһԤ?

ýͱֽ,OMPϢ֪ҪǶ?Ц
,ʼܾ˵:ʵʽԹ!Ҳ̫ɲꡢû˰!

ýͱֽ,ţ˾ֻںʱ?Ŀ
谷¼ţ˵,ӦöʳƷȫϢ¶̵ķʡ
Ľ֮ǰѧ߷ӵɺڵ,OMPǡȫб
֤,ΪûʱӦ?߲ǵġʳĸ?̹
ϵı,ѵһҵĸٶ?

OMP¼ձضһ˵,ֻ,ڰʶOMPĹ,
ǵ֪Ȩһα,,ǰնʳƷȫľԱ
ԭ?ڹİյOMP֪Ȩ,һᵽ
κСOMP:ŶƭOMP

(XYS20090213)

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ʼ칤ʱܴ

ߣ
Դ

ĿѪҪԵʵǵö¹̷۵
鴦Ϊ200712½յߵͶߡûͶߣ˭
ȥ˼谷İȫ⣿ҪǹѧרҷڶOMP
֤ɣţջʼֵܾô

ʼ칤¹ʳƷҩƷİȫ¹ȶĴ֣Ҫ
˽֪ȻһδʳƷȫ¹ʵķӣҵ̵
ֱԭ򣬲ʼ첿Źͺ򲻵кܴĹϵô硰谷
¶ͷʼ첿žɱҡ֮Уϲڻᵼ³ǧ
޹ͯ亦ʼֶܾеOMPʵİȫԳǰо
׼ȷգǰͨϲùһͷˮɲҪĽźͿ
š

ȻʼܾޣԶȫҵĲƷʼ죬
Ϊ¹ţشҵӦץڵطʼ칤
ҲӦ顢ָͼලΡ˵ʼֹܾΣЩ
ԩּƺǷҡöţյʼ˵
Ȼ IGF-1ţ̲Ϸɷ棬Ϊרıг֣
ţר100ӵIGF-1Ϊһţ̵򱶡Ȼߣ
ɶֻգΪ֮ǰûⷽļоȻֱĿǰ
оOMPİȫԡⲻǹͺ˵ʲôأ

ʼ족롰Ρйġʼ칤ĺûȡΡ
ǿʼ칤ЧҲԡ֮ʶǿʹ
ʼ칤Ҳͻۿۡԣҹʼ칤ǱȽϺõģ
رǶԳڲƷļ⹤֮ڵһЩ⡣

ţҵгƣOMPIGF-1䰲ȫܵFDAȹȨ
ϿɣOMPԭϾTATUA˾ڣԭϾ˺غͽ
ڼ߲ϸ顣һжʵ⾿ԭ
ϱʹ⣬ûм˵ʲô⣿˵ʼ칤
ҪһǿĺԣŬǿѧԣŬĿѧ
ͽȫһ׿ѧġļϵЩⲻƽʼ칤
ͻϴ򱻶̣ʳƷȫİѹϣͻһδԹ
ʵɡͤʧء

(XYS20090213)

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ʵΪ۳дѧïʵġ

ߣtoxys

,ú˼,Ҳ˵. ˵,Һµߺ
ᵽĵûκιϵ.

˵˵бҪµ¼.

(1), ڸʱ, ҲҪԷӲο׵
. Ϊÿ˶׵ľ, /пû/Լо
,.

(2)Ҳǵĸʱ,ҪӲο׵.ûʲô
ϣ.˿Ұ.

(3)һ˵,˼ҪӲο, 㲻һǵҪ. Ϊֻ
˵. ı༭ṩ˵ʱ,/Ὠ㰴
˵޸,һ˵:㲻ͬ˵,.
,༭ǻܵ. ǹΪöӲο,
гɸ߿ı༭.

һڵ.

(1)    ܿ϶Ǹï?ȷʵ
ï,ͷǳΣ,Ϊ/ڮ.

(2)    ,ҪЩο׵ĿĻǺ
Ϊµ? ڲͬ˿Ĺ۵㲻ͬ, 
ºЩ,ҪЩοҲûʲôԵ.
û˵˲ҪԼ.

(3)    áƪ¹ϵ,˼ûҪ.
ΪʲôҪ? ȫԸı༭˵,ǿı༭ǻܵ.

(4)    һ˵,Ȼáƪ¹ϵ,
Ӧý.ôһӿİͳɱ,
һҲǶԶ߲,Ϊ߻ỨʱȥЩ.

(5)    Щ¸˼ʵԩ,
һЩõĶʹһЩ޹ؽҪ,㻹Ҫ
༭³.

(XYS20090213)

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и˼ġҩִǲܡ

ߣ98

˼дҩִǲܣҲǲʵǣִ
ֻҽִѧֻ"ҩ""ҽ"Щν
ŵҽۡ

һ㣬ҽӴĲҩѧѧĿƼԱͬеġ
ǵĸѧָϣʵ޻˵

ĹȻѧҽҩѧƵָй涨ڽĳ
ҩɷΪ ҽҩ˼ά֮ʵĿٴʵ
Ŀ һɲķкҵʵĿڿͶ
ҩйصı飬ͶҲСһĿ973õķʽרŻһ
ҽҩ973ɹҽҩִܡһ׼ܡ
ҽҩ

֮һҪôҵġšҪôҵġй
ҽһҽҽָ¸ҩûеڶ·λ
ַ˴ƣһҪԼķʽҪҵľԼоҩϷ

(XYS20090213)

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ｭҩ޹˾ľ˹ֹ˾˫עҺͣ

»£յ磨ʳƷҩƷܾ֣
ս֪ͨͣúｭҩ޹˾ľ˹ֹ˾˫ע
Һ

ꣲ£գʳƷҩƷֽܾӵຣʡ棬ຣʡ
ͨأʹñʶΪｭҩ޹˾ľ˹ֹ
˾˫עҺţ񣲣
֧¼档

ΪȷٴҩȫҪҽƻҩƷӪҵ
ͣʹá۲ｭҩ޹˾ľ˹ֹ˾ġ˫
עҺһֲ¼ߣҪȫҽƾι涨ʱ
źҩಿű档

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